Testosterone replacement therapy has been proven safe and effective over decades, for treatment of men with recognised problems of the pituitary or testis that cause androgen deficiency. Testosterone treatment has not been proven safe and effective for older men without any recognised disorders of the pituitary or testis. Until further evidence is available, testosterone treatment of such older men can not be recommended.
In the wider community, abuse of androgens in sport is also an important issue with some elite athletes and body builders using massive doses of androgens. For athletes this breaks the rules against sports doping and for all androgen abusers, the long-term affects on the body particularly for prostate (prostate cancer, BPH) and cardiovascular diseases (heart attack, stroke) remain of great concern.